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evidence of CoQ10 deficiency in heart failure. Recently, CoQ10 plasma
concentrations have been demonstrated as an independent predictor of mortality
in chronic heart failure, CoQ10 deficiency being detrimental to the long-term
prognosis of chronic heart failure. CoQ10 is available as
medicine in several European countries, but is in these countries also
available as a food supplement. Oxidation of the circulating LDL is thought to
play a key role in the pathogenesis of atherosclerosis, which is the
underlying disorder leading to heart attack and ischemic strokes
and CHD. Studies in the last decade have demonstrated that the content of
Ubiquinol in human LDL affords protection against the oxidative modifications
of LDL themselves, thus lowering their atherogenic potency.
human studies.A recent (2007) meta-analysis of the clinical trials of CoQ10
for hypertension reviewed all published trials of coenzyme Q10 for
hypertension, and assessed overall efficacy, consistency of therapeutic
action, and side-effect incidence. Meta-analysis was performed in 12 clinical
trials (362 patients) comprising three randomized controlled trials, one
crossover study, and eight open-label studies. The meta-analysis concluded
that coenzyme Q10 has the potential in hypertensive patients to lower systolic
blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm
Hg without significant side-effects.
the same process as that of lipids and the uptake mechanism appears to be
similar to that of vitamin E, another lipid-soluble nutrient.This process in
the human body involves the secretion of pancreatic enzymes and bile into the
small intestines that facilitate emulsification and micelle formation that is
required for the absorption of lipophilic substances. Food intake (and the
presence of lipids) stimulates bodily biliary excretion of bile acids and
greatly enhances the absorption of CoQ10. Exogenous CoQ10 is absorbed from the
small intestinal tract and is best absorbed if it is taken with a meal. Serum
concentration of CoQ10 in fed condition is higher than in fasting conditions.
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