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Coenzyme Q10



Coenzyme Q10


Heart health

Coenzyme Q10 helps to maintain a healthy cardiovascular system. There is
evidence of CoQ10 deficiency in heart failure. Recently, CoQ10 plasma 
concentrations have been demonstrated as an independent predictor of mortality 
in chronic heart failure, CoQ10 deficiency being detrimental to the long-term 
prognosis of chronic heart failure.[40][citation needed] CoQ10 is available as 
medicine in several European countries, but is in these countries also 
available as a food supplement. Oxidation of the circulating LDL is thought to 
play a key role in the pathogenesis of atherosclerosis, which is the 
underlying disorder leading to heart attack and ischemic strokes[41][42][43] 
and CHD. Studies in the last decade have demonstrated that the content of 
Ubiquinol in human LDL affords protection against the oxidative modifications 
of LDL themselves, thus lowering their atherogenic potency.

Blood pressure

There are several reports concerning the effect of CoQ10 on blood pressure in
human studies.A recent (2007) meta-analysis of the clinical trials of CoQ10 
for hypertension reviewed all published trials of coenzyme Q10 for 
hypertension, and assessed overall efficacy, consistency of therapeutic 
action, and side-effect incidence. Meta-analysis was performed in 12 clinical 
trials (362 patients) comprising three randomized controlled trials, one 
crossover study, and eight open-label studies. The meta-analysis concluded 
that coenzyme Q10 has the potential in hypertensive patients to lower systolic 
blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm 
Hg without significant side-effects.

Absorption

CoQ10 is a crystalline powder that is insoluble in water. Absorption follows
the same process as that of lipids and the uptake mechanism appears to be 
similar to that of vitamin E, another lipid-soluble nutrient.This process in 
the human body involves the secretion of pancreatic enzymes and bile into the 
small intestines that facilitate emulsification and micelle formation that is 
required for the absorption of lipophilic substances.[13] Food intake (and the 
presence of lipids) stimulates bodily biliary excretion of bile acids and 
greatly enhances the absorption of CoQ10. Exogenous CoQ10 is absorbed from the 
small intestinal tract and is best absorbed if it is taken with a meal. Serum 
concentration of CoQ10 in fed condition is higher than in fasting conditions.



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